办公地点

伟德bv1946官网306

办公电话

0431-85619702

邮箱

shiyan@jlu.edu.cn

教育背景

2000-2006 BV伟德国际1946 硕博连读 

1993-1998白求恩医科大学临床医学系 本科生

工作经历

2012-至今，BV伟德国际1946，伟德bv1946官网，副教授

2004-2012, BV伟德国际1946, 伟德bv1946官网, 讲师

2003-2004, BV伟德国际1946, 再生医学研究所, 助教

1998-2000, 白求恩医科大学, 预防医学院, 助教

主讲课程

人类疾病动物模型的复制

研究领域

内分泌与肿瘤药理学；分子药理学；网络药理学

科研成果

1. Xuerui Guo#, Li Wang#, Jinlong Zhang#, Quan Liu, Bingmei Wang, Da Liu，Fei Gao,

Gongga Lanzi*, Yicheng Zhao*, Yan Shi*:Thwarting Resistance: MgrA Inhibition with

Methylophiopogonanone A Unveils a New Battlefront Against S. aureus, NPJ biofilms and microbiomes vol. 10,1 15. 27 Feb. 2024, doi:10.1038/s41522-024-00485-w.

2. Ming Zhang， Yingli Jin， Xuerui Guo，Wanxin Shan， Jinlong Zhang，

Aoxue Yuan， Yan Shi， Resveratrol protects mesangial cells under high glucose by regulating the miR-1231/IGF1/ERK pathway，Environmental Toxicology. 2024;39:2326–2339，DOI: 10.1002/tox.24103

3. XinranRen,XueruiGuo,ChangLiu,ShisongJing,TiedongWang,LiWang,JiyuGuan,WuSong,YichengZhao,YanShi.Natural flavone hispidulin protects mice from Staphylococcus aureus pneumonia by inhibition of α-hemolysin production via targeting AgrAC. Microbiological Research, 2022，261:127071.

4. Chen, Chen [1] ; Shi, Y (Shi, Yan) [1] ; Ma, JL (Ma, Jiulong) [1] ; Chen, Z (Chen, Zhen) [1] ; Zhang, M (Zhang, Ming) [1] ; Zhao, Y (Zhao, Yan) [2],Trigonellinereverses high glucose‑induced proliferation, fibrosis of mesangial cells via modulation of Wnt signaling pathway.DIABETOLOGY & METABOLIC SYNDROME，2022，（14）28.DOI10.1186/s13098-022-00798-w

5. Shisong Jing , Li Wang , Tiedong Wang , Lianghai Fan , Lin Chen , Hua Xiang ,Yan Shi , Dacheng Wang .Myricetin protects mice against MRSA-related lethal pneumonia by targeting ClpP. Biochemical Pharmacology .2021,192: 114753

6. Chen Chen , Jiulong Ma , Chun Sheng Miao , Huayu Zhang , Ming Zhang a, Xia Cao , Yan Shi *.Trigonelline induces autophagy to protect mesangial cells in response to high glucose via activating the miR-5189-5p-AMPK pathway. Phytomedicine2021（92） ：153614