Publication [1] LIANG Chong-Yang, XU Wei-Qing, CAO Yan-Xin, LIU Li-Xia, ZHANG Shu-Qin, LIU Zhi-Yi, LI Hong-Rui, LI Bai-Zhi, SUN Fei. Dynamic Observation of Cellular Localization of Fluorescein Isothiocyanate Labeled Recombinant Ganoderma Lucidum Immunoregulatory Protein(rLz-8) in NB4 APL Cell[J]. Chemical Journal of Chinese Universities, 2009, 30(3):489-492. 2009 Mar [2] Chongyang Liang, Shuqin Zhang, Zhiyi Liu, Fei Sun. Ganoderma lucidum immunomodulatory protein(Lz-8) expressed in Pichia pastoris and the identification of immunocompetence. Sheng Wu Gong Cheng Xue Bao. 2009;25(3):441-447. 2009 Mar [3] ZHANG Shu-qin, LIU Zhi-yi, ZHANG Fu-ming, SUN Fei. Preparation of arbidol hydrochloride multi-layers controlled-released and evaluation of its release rate in vivo and in vitro[J]. Journal of Jilin University Medicine Edition, 2009, 35(4):758-761. 2009 Apr [4] Liang Huang, Fei Sun, Chongyang Liang, Yong-Xing He, Rui Bao, Lixia Liu, Cong-Zhao Zhou. Crystal structure of LZ-8 from the medicinal fungus Ganoderma lucidium. Proteins. 2009;75(2):524-527. doi:10.1002/prot.22346 2009 May 1 [5] Xumei Wang, Shuping Xu, Chongyang Liang, Hongrui Li, Fei Sun, Weiqing Xu. Enriching PMMA nanospheres with adjustable charges as novel templates for multicolored dye@PMMA nanocomposites. Nanotechnology. 2011;22(27):275608. doi:10.1088/0957-4484/22/27/275608 2011 Jul 8 [6] Chongyang Liang, Hongrui Li, Hui Zhou, Shuqin Zhang, Zhiyi Liu, Qiuli Zhou, Fei Sun. Recombinant Lz-8 from Ganoderma lucidum induces endoplasmic reticulum stress-mediated autophagic cell death in SGC-7901 human gastric cancer cells. Oncol Rep. 2012;27(4):1079-1089. doi:10.3892/or.2011.1593 2012 Apr [7] Yuequn Cao, Chongyang Liang, Yong Zhang, Jianlin Lin, Fei Sun. New purification process of fungal immunomodulatory protein, FIP-fve from Flammulina velutipes via filtration and column chromatography[J]. African Journal of Biotechnology, 2013, 12(5):512-519. 2013 [8] Xiping Zhang, Fei Sun, Zhiyi Liu, Shuqin Zhang, Chongyang Liang. Recombinant Ganoderma lucidum immunomodulatory protein modified with polyethylene glycol. Mol Med Rep. 2013;7(3):975-980. doi:10.3892/mmr.2013.1281 2013 Mar [9] Hui Zhou, Fei Sun, Hongrui Li, Shuqin Zhang, Zhiyi Liu, Jin Pei, Chongyang Liang. Effect of recombinant Ganoderma lucidum immunoregulatory protein on cyclophosphamide-induced leukopenia in mice. Immunopharmacol Immunotoxicol. 2013;35(3):426-433. doi:10.3109/08923973.2013.791834 2013 Jun [10] Xilin Sun, Wei Huang, Sijia Xiao, Chongyang Liang, Shuqin Zhang, Zhiyi Liu, Fei Sun. Extracellular expression and efficient purification of a functional recombinant Volvariella volvacea immunomodulatory protein (FIP-vvo) using Pichia pastoris system. Protein Expr Purif. 2014;94:95-100. doi:10.1016/j.pep.2013.10.022 2014 Feb [11] HOU Yue; SUN Fei; JIN Jing; LIU Zhiyi; ZHENG Qingchuan; LIANG Chongyang. Expression and Molecular Dynamics of Recombinant Ganoderma Lucidum Immunoregulatory Protein-IgG Fc(LZ8-Fc) Fusion Protein in Pichia pastoris[J]. 高等学校化学学报, 2014, 35(2):303-308. 2014 Feb [12] Wei Wei, Haoran Guo, Jingliang Li, Sangsang Ren, Zhenhong Wei, Wanguo Bao, Xiaoming Hu, Ke Zhao, Wenyan Zhang, Yulai Zhou, Fei Sun, Richard Markham, Xiao-Fang Yu. Circulating HFMD-associated coxsackievirus A16 is genetically and phenotypically distinct from the prototype CV-A16. PLoS One. 2014;9(4):e94746. Published 2014 Apr 15. doi:10.1371/journal.pone.0094746 2014 Apr 15 [13] He Guo, Fei Sun, Wei Huang, Zhiyi Liu, Shuqin Zhang, Qiuli Zhou, Chongyang Liang. The effect of rhG-CSF on spleen transcriptome in mouse leukopenia model induced by cyclophosphamide. Immunopharmacol Immunotoxicol. 2014;36(2):114-123. doi:10.3109/08923973.2013.869696 2014 Apr [14] Minghe Li, Zhihong Li, Chongyang Liang, Chengmin Han, Wei Huang, Fei Sun. Upregulation of GRIM-19 suppresses the growth of oral squamous cell carcinoma in vitro and in vivo. Oncol Rep. 2014;32(5):2183-2190. doi:10.3892/or.2014.3423 2014 Nov [15] Fei Sun, Xining Li, Chen Yang, PengLv, Guangsheng Li, HuiXu. A role for PERK in the mechanism underlying fluoride-induced bone turnover. Toxicology. 2014;325:52-66. doi:10.1016/j.tox.2014.07.006 2014 November [16] Minghe Li, Zhihong Li Jia Li, Liou Jin, Chengxue Jin, Chengmin Han, Xin Ji, Fei Sun. Enhanced antitumor effect of cisplatin in human oral squamous cell carcinoma cells by tumor suppressor GRIM‑19. Mol Med Rep. 2015;12(6):8185-8192. doi:10.3892/mmr.2015.4423 2015 Dec [17] Gefu Chi, Weiting Zhong, Yan Liu, Gejin Lu, Hongming Lü, Dacheng Wang, Fei Sun. Isorhamnetin protects mice from lipopolysaccharide-induced acute lung injury via the inhibition of inflammatory responses. Inflamm Res. 2016;65(1):33-41. doi:10.1007/s00011-015-0887-9 2016 Jan [18] Biao Zhang, Baizhi Li, Dai Chen, Jie Zong, Fei Sun, Huixin Qu , Chongyang Liang. Transcriptional Regulation of Aerobic Metabolism in Pichia pastoris Fermentation. PLoS One. 2016;11(8):e0161502. Published 2016 Aug 18. doi:10.1371/journal.pone.0161502 2016 Aug 18 [19] Lu Dai, Weikang Li, Fei Sun, Baizhi Li, Hongrui Li, Hongxing Zhang, Qingchuan Zheng, Chongyang Liang. A strategy of designing the ligand of antibody affinity chromatography based on molecular dynamics simulation. J Chromatogr A. 2016;1463:81-89. doi:10.1016/j.chroma.2016.08.004 2016 Sep 9 [20] Jing Jin, Yanting Shen, Biao Zhang, Rong Deng, Dianshuai Huang, Tianqi Lu, Fei Sun, Shuping Xu, Chongyang Liang. In situ exploration of characteristics of macropinocytosis and size range of internalized substances in cells by 3D-structured illumination microscopy. Int J Nanomedicine. 2018;13:5321-5333. Published 2018 Sep 12. doi:10.2147/IJN.S171973 2018 Sep 12 [21] Jing Jin, Yilong Zhu, Fei Sun, Zhifei Chen, Shuang Chen, Yiquan Li, Wenjie Li, Min Li, Chuanxin Cui, Yingli Cui, Xunzhi Yin, Shanzhi Li, Jin Zhao, Guo Yan , Xiao Li, Ningyi Jin. Synergistic antitumor effect of the combination of a dual cancer-specific oncolytic adenovirus and cisplatin on lung cancer cells. Oncol Lett. 2018;16(5):6275-6282. doi:10.3892/ol.2018.9470 2018 Nov [22] Huan Tang, Jinglin Chen, Lin Wang, Qianwen Li, Yue Yang, Zhe Lv , Han Bao , Yao Li , Xue Luan, Yan Li , Zhihui Ren , Xiaowei Zhou , Dengli Cong , Zhiyi Liu , Juan Jia , Hongyu Chen, Weitao Zhao , Qin Meng , Fei Sun, Jin Pei. Co-delivery of epirubicin and paclitaxel using an estrone-targeted PEGylated liposomal nanoparticle for breast cancer. Int J Pharm. 2020;573:118806. doi:10.1016/j.ijpharm.2019.118806 2020 Jan 5 [23] Han B, Yang Y, Chen J, Tang H, Sun Y, Zhang Z, Wang Z, Li Y, Li Y, Luan X, Li Q, Ren Z, Zhou X, Cong D, Liu Z, Meng Q, Sun F, Pei J. Preparation, Characterization, and Pharmacokinetic Study of a Novel Long-Acting Targeted Paclitaxel Liposome with Antitumor Activity. Int J Nanomedicine. 2020;15:553-571. Published 2020 Jan 24. doi:10.2147/IJN.S228715 2020 Jan 24 [24] Dianshuai Huang, Qingjie Fan, Zhiyi Liu, Shuqin Zhang, Wei Huang, Hongrui Li, Chongyang Liang, Fei Sun. An Epitope on EGFR Loading Catastrophic Internalization Serve as a Novel Oncotarget for Hepatocellular Carcinoma Therapy. Cancers (Basel). 2020;12(2):456. Published 2020 Feb 16. doi:10.3390/cancers12020456 2020 Feb 16 [25] Dianshuai Huang, Tianqi Lu, Xingyu Du, Xi Xi, Xin Zhang, Xitian Zhang, Haoran Zhang, Fei Sun. Lattice complex assembled by noncompetitive anti-EGFR antibodies regulates actin cytoskeletal reorganization. Cancer Cell Int. 2020;20:129. Published 2020 Apr 21. doi:10.1186/s12935-020-01204-z 2020 Apr 21 [26] Yong Yang, Tian Yu, Huan Tang, Zhihui Ren, Qianwen Li, Juan Jia, Hongyu Chen], Jun Fu , Shengchen Ding, Qiang Hao, Dan Xu, Liping Song, Bo Sun, Fei Sun, Jin Pei. Ganoderma lucidum Immune Modulator Protein rLZ-8 Could Prevent and Reverse Bone Loss in Glucocorticoids-Induced Osteoporosis Rat Model. Front Pharmacol. 2020;11:731. 2020 May 19. doi:10.3389/fphar.2020.00731 2020 May 19 [27] Xinhua Lei, Chenyang Zhi, Wei Huang, Xilin Sun, Weiyang Gao, Xue Yin, Xin Zhang, Chongyang Liang, Haoran Zhang, Fei Sun. Recombinant Ganoderma lucidum Immunomodulatory Protein Improves the Treatment for Chemotherapy-Induced Neutropenia. Front Pharmacol. 2020;11:956. Published 2020 Jun 26. doi:10.3389/fphar.2020.00956 2020 Jun 26 [28] Xi Xi,Wei han Sun,Hang Su,Xitian Zhang,Fei Sun. Identification of a novel anti-EGFR nanobody by phage display and its distinct paratope and epitope via homology modeling and molecular docking.Molecular Immnunology.2020;128:165-174. Patent 1 Recombinant Ganoderma Lucidium immunomodulartory protein (rLZ-8) and uses thereof. Fei Sun、Lixia Liu、Shoumin Xu、Chongyang Liang、Xitian Zhang China 2012.1.4 ZL200810050206.X 2 Application of Recombinant Ganoderma Lucidium immunomodulartory protein (rLZ-8) in thrombocytopenia and uses thereof. Fei Sun、Chongyang Liang、Xitian Zhang. China 2012.6.20 ZL200910143424.2 3 Methoxypolyethyleneglycol succinimidyl propionate modified recombinant ganoderma immunoregulatory protein, preparing method and application thereof. Fei Sun、Chongyang Liang、Xitian Zhang. China 2014.3.12 ZL201210243582.7 4 Application of recombinant immunoregulatory protein of ganoderma lucidum in preparation of drug for treating focal cerebral ischemia. Fei Sun、Chongyang Liang、Xitian Zhang. China 2014.9.3 ZL201310402259.4 5 Fusion Protein of Recombinant Ganoderma Lucidum Immunoregulatory Protein and Human Serum Albumin, Preparation Method Therefor and Application Thereof. Fei Sun、Chongyang Liang、Xitian Zhang. China 2015.1.7 ZL201310479016.0 6 Recombinant Ganoderma Lucidium immunomodulartory protein (rLZ-8) and uses thereof. Fei Sun、Chongyang Liang、Xitian Zhang. Australia 2015.1.15 2008349094 7 Applications of Recombined Ganoderma Lucidum Immunoregulation Protein in Preparing Drugs for Treating Tissue Fibrosis. Fei Sun、Chongyang Liang、Xitian Zhang. China 2015.2.25 ZL201410048713.5 8 Applications of Recombined Ganoderma Lucidum Immunoregulation Protein in Preparing Drugs for Treating osteoporosis. Fei Sun、Chongyang Liang、Xitian Zhang. China 2015.3.25 ZL201410266772.X 9 Methoxypolyethyleneglycol succinimidyl propionate modified recombinant ganoderma immunoregulatory protein, preparing method and application thereof. Fei Sun、Chongyang Liang、Xitian Zhang. Taiwan 2015.4.1 I478725 10 Recombinant Ganoderma Lucidium immunomodulartory protein (rLZ-8) and uses thereof. Fei Sun、Xitian Zhang. Japan 2015.4.24 2010-541002 11 Applications of Recombined Ganoderma Lucidum Immunoregulation Protein in Preparing Drugs for Treating chronic heart failure. Fei Sun、Chongyang Liang、Xitian Zhang. China 2015.4.29 ZL201410098980.3 12 Use of recombinant ganoderma immunoregulatory protein (rLZ-8) in preparation of drug for treating melanoma. Fei Sun、Chongyang Liang、Xitian Zhang. China 2015.6.17 ZL201310357176.8 13 Applications of Recombined Ganoderma Lucidum Immunoregulation Protein in Preparing Drugs for Treating Androgenetic Alopecia. Fei Sun、Chongyang Liang、Xitian Zhang. China 2015.7.1 ZL201410254129.5 14 Applications of Recombined Ganoderma Lucidum Immunoregulation Protein in Preparing Drugs for regulating the contents of lipoprotein in blood lipids. China 2015.11.11 ZL201410362924.6 15 Application of recombinant immunoregulatory protein of ganoderma lucidum in preparation of drug for treating focal cerebral ischemia. Fei Sun、Chongyang Liang、Xitian Zhang. The United Kingdom 2016.6.8 3028712 16 Application of recombinant immunoregulatory protein of ganoderma lucidum in preparation of drug for treating focal cerebral ischemia. Fei Sun、Chongyang Liang、Xitian Zhang. France 2016.6.8 3028712 17 Application of recombinant immunoregulatory protein of ganoderma lucidum in preparation of drug for treating leukopenia. Fei Sun、Lixia Liu、Shoumin Xu、Chongyang Liang、Xitian Zhang China 2016.9.28 ZL201110222012.5 18 Recombinant Ganoderma Lucidium immunomodulartory protein (rLZ-8) and uses thereof. Fei Sun、Xitian Zhang. Japan 2016.11.11 2014-245808 19 Fusion Protein of Recombinant Ganoderma Lucidum Immunoregulatory Protein and Human Serum Albumin, Preparation Method Therefor and Application Thereof. Fei Sun、Chongyang Liang、Xitian Zhang. Australia 2017.2.23 2014336815 20 Application of recombinant immunoregulatory protein of ganoderma lucidum in preparation of drug for treating focal cerebral ischemia. Xitian Zhang、Fei Sun. European Union 2017.5.31 3028712 21 Use of recombinant ganoderma immunoregulatory protein (rLZ-8) in preparation of drug for treating melanoma. Fei Sun、Chongyang Liang、Xitian Zhang. European Union 2017.9.28 3023104 22 Applications of Recombined Ganoderma Lucidum Immunoregulation Protein in Preparing Drugs for Treating Tissue Fibrosis. Fei Sun、Chongyang Liang、Xitian Zhang. United State of America 2017.10.17 9789158 23 Use of recombinant ganoderma immunoregulatory protein (rLZ-8) in preparation of drug for treating melanoma. Fei Sun、Chongyang Liang、Xitian Zhang. Russia 2018.3.29 2649129 24 Fusion Protein of Recombinant Ganoderma Lucidum Immunoregulatory Protein and Human Serum Albumin, Preparation Method Therefor and Application Thereof. Fei Sun、Chongyang Liang、Xitian Zhang. Germany 2015.1.7 3034515 25 Fusion Protein of Recombinant Ganoderma Lucidum Immunoregulatory Protein and Human Serum Albumin, Preparation Method Therefor and Application Thereof. Fei Sun、Chongyang Liang、Xitian Zhang. Japan 2019.2.8 6475698 26 Recombinant Ganoderma Lucidium immunomodulartory protein (rLZ-8) and uses thereof. Fei Sun、Chongyang Liang、Xitian Zhang. Canada 2019.10.21 2711207 27 Mutants of recombinant immunoregulatory protein of Ganoderma lucidum and applications thereof. Fei Sun、Chongyang Liang. China 2020.7.3 CN107118263 B Approval certificate of new drug clinical trials: 1. Clinical trial I of the injected ZZ06 in treating advanced EGFR-positive solid tumor Pending number：CXSL2000125, Notice certificate number：2020LP00270。State Drug Administration. 2. ZZ06(lyophilized powder for intravenous injection) Investigational new drug application（IND）IND137344 U.S. Food and Drug Administration. |
