Address

Room 612, School of Pharmaceutical Sciences

Tel.

0431-85619260

Email

xbai@jlu.edu.cn

Education Background

Ph.D., Organic Chemistry. University of North Carolina, Chapel Hill, NC, 1990.

B.S., Chemistry. Jilin University, Changchun, China, 1984.

Work Experience

Jilin University, Changchun, China, June 2000 – ,

Professor & Doctoral Supervisor, Founder and Director ( 2000 - 2019) of the Center for Combinatorial Chemistry and Drug Discovery

Du Pont Pharmaceuticals Research Laboratories, San Diego, CA, January, 2000-June, 2000 Senior Research Scientist

Combichem, Inc. (acquired by Du Pont Pharmaceuticals), San Diego, CA. 1997-2000

Principal Research Scientist/Group Leader, January, 1999-November, 1999

Senior Research Scientist/Group Leader, 1997-1998

IDUN Pharmaceuticals, Inc., San Diego, CA. 1994-1997.

Senior Scientist. 1996-1997.

Staff Scientist. 1994-1996.

Natland International Corporation, NC. 1993-1994.

Co-founder, President, and R&D Director.

Research Triangle Institute, Research Triangle Park, NC. 1990-1993.

Postdoctoral Chemist, Department of Medicinal Chemistry.

University of North Carolina, Chapel Hill, NC. 1985-1990.

Graduate Research Assistant.

Courses

Research Field

Synthetic Medicinal Chemistry

Scientific Research Achievements

Selected publications：

1. Guoxing Xu, Xu Bai, and Qun Dang*, ”Aromatic Heterocycles as Productive Dienophiles in the Inverse Electron-Demand Diels−Alder Reactions of 1,3,5-Triazines”, Acc. Chem. Res. 2020, 53, 773−781.

2. Kai Yang, Qun Dang, Pei-Jun Cai, Yang Gao, Zhi-Xiang Yu*, and Xu Bai*, “Reaction of Aldehydes/Ketones with Electron-Deficient 1,3,5-Triazines Leading to Functionalized Pyrimidines as Diels-Alder/Retro-Diels-Alder Reaction Products: Reaction Development and Mechanistic Studies”, J. Org. Chem., 2017, 82, 2336-2344.

3. Jinbao Xiang, Hongxiang Xie, Zhuo Li, Qun Dang, and Xu Bai* , “Stereoselective Synthesis of 3‑Carboxy-4,5-dihydropyrroles via an Intramolecular Iminium Ion Cyclization Reaction”, Org. Lett., 2015, 17(15), 3818−3821.

4. Yuewei Zhang, Fengzhi Yang, Lianyou Zheng, Qun Dang, and Xu Bai* “A Cascade of Acid-Promoted C−O Bond Cleavage and Redox Reactions: From Oxa-Bridged Benzazepines to Benzazepinones”, Org. Lett. 2014, 16, 6041−6043.

5. Kai Yang, Jinbao Xiang*, Guochen. Bao, Qun. Dang*, Xu Bai, “Synthesis of Highly Substituted 4H‑Pyrido[1,2‑a]pyrimidines via a One-Pot Three-Component Condensation Reaction” ACS Comb. Sci. 2013, 15, 519–524.